RIPK3 and non-small cell lung carcinoma: Ablative hypofractionated radiation therapy at ≥10 Gy per fraction enhances killing of non-small cell lung cancer with high receptor interacting serine/threonine kinase (RIPK)-3 expression via preferential stimulation of necroptosis 9, as a caspase-independent form of ICD 10-12, which is induced in apoptosis-resistant cells 13, 14 and involves the activation of RIPK1, RIPK3, and the pseudokinase mixed lineage kinase like (MLKL) 14, 15.