PTEN and hepatocellular carcinoma: Alternatively, although BRD7 was found to be involved in the PI3K pathway by ChIP-seq analysis (Figure 1C and Figure S1C), overexpression or knockdown of BRD7 in HCC cells did not significantly affect the protein levels of PTEN, Akt, and p-Akt which are central components in the PI3K pathway (Figure 6B).