Even though MACC1-AS1 was involve in the progression of gastric cancer, pancreatic cancer, hepatocellular carcinoma, lung cancer, cervical squamous cell carcinoma, nasopharyngeal carcinoma and glioma, the dysfunction pattern of MACC1-AS1/ MACC1 only existed in some certain cancers, which provided more possibility of chasing the precise target of oncotherapy. The gene discussed is MACC1; the disease is hepatocellular carcinoma.