EGF and head and neck squamous cell carcinoma: For example, it is acknowledged that there are various O-glycan-decorated Notch receptors distributed in the extracellular domain epidermal growth factor-like (EGF) repeats 136, and many human congenital diseases are caused by O-glycosylation defects on Notch receptors; however, the relationship between the O-glycosylation defect of the Notch receptor and HNSCC has not been reported.