COL11A1 and cancer: Therefore, the fragment of COL11A1 promoted the expression of the full-length COL11A1.To investigate whether COL11A1 affects the proliferation of pancreatic cancer cells and their resistance to GEM, we increased and knocked down COL11A1 in cancer cells using COL11A1-coated plates and treatment with siRNA against COL11A1, respectively, with or without GEM treatment.