The coexpression analysis indicated that IGFBP7 was highly positively correlated with the top eight coexpressed genes (LHFPL6, MGP, SEPTIN4, HSPB2, ACTA2, LAYN, NDN, and GGT5), and all these genes served as risk factors for unfavorable survival of GC. This evidence concerns the gene HSPB2 and gastric cancer.