GPT and colitis: Among patients treated with ICI combination therapy, fatigue (RR 5.11, 95% CI 2.68-9.76, p < 0.00001), nausea (RR 4.35, 95% CI 1.15-16.48, p = 0.03), diarrhea (RR 2.48, 95% CI 1.62-3.79, p < 0.0001), colitis (RR2.52, 95% CI 1.59-3.98, p < 0.0001), rash (RR 4.02, 95% CI 1.86-8.66, p = 0.0004), pruritus (RR 11.36 , 95% CI 1.42-91.03, p = 0.02), elevated ALT (RR 7.28, 95% CI 3.77-14.04, p < 0.00001), elevated AST (RR 5.76, 95% CI 2.85-11.63, p < 0.00001), elevated lipase (RR 3.44, 95% CI 1.36-8.74, p = 0.009) were higher than ICI monotherapy.