CD4 and neoplasm: By analyzing the data from Tumor Immune Estimation Resource (TIMER), we found that ANXA1 expression closely correlated with the infiltration level of B cell (R=0.477), CD4+ T cell (R=0.425), neutrophil (R=0.386) and dendritic cell (R=0.376) in PTC, implying ANXA1 may influence the chemotaxis of certain types of immune cells to mediate the immune escape in the PTC microenvironment (Fig. 6F).