The underlying key genes in asthma pathogenesis and those regulated by treatment including Adipoq, HMOX1, SPP1, Cyp2e1, TNC, MB, MPO, Col9a1, Ckmt2, and Erbb4 were taken as examples to illustrate the positions and relationships with other points and midline in the figure. This evidence concerns the gene HMOX1 and asthma.