In addition to these main pathways, IGF-IR is able to activate the Janus kinases/signal transducer and activator of transcription proteins (JAK/STAT) pathway and Wnt and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling [45] IGF-1 induces VEGF production in MM cells through the MEK/ERK pathway, which increases angiogenesis in the BM [46, 47]. Here, MAP2K7 is linked to Miyoshi myopathy.