This enzyme plays a role in the biosynthesis of phosphatidylethanolamine, a main constituent of cell membranes.31 Only a few previous reports of association between ETNK2 and malignancies and one report suggested that a higher level of CpG methylation in the ETNK2 promoter was related to radiotherapy resistance in laryngeal squamous cell carcinoma.32 However, in general, little is known about the function of ETNK2 in GI tract cancers, including GC. This evidence concerns the gene ETNK2 and laryngeal squamous cell carcinoma.