CD274 and neoplasm: However, patient stratification and personalised treatments are required to get the most from this cancer treatment strategy.2 For this purpose, the immune baseline status of tumours, regarding certain markers such as T cell infiltration, chemokine profiles, major histocompatibility complex (MHC) class I, and programmed death-ligand 1 (PD-L1) expression, is crucial.2 Indeed, these specific characteristics have been used for tumour classification into inflamed or hot tumours, and non-inflamed or cold tumours.