We also observed an increase of CD8+ T cells over CD4+ T cells in the TDLNs, peripheral blood and tumour rechallenge site of immunised mice; these results correspond with the observations that in the same host, memory assessments result in robust CD8+ T-cell responses, but poor boosting of CD4+ T-cell recall responses,60 which is correlated with the demonstration that CD4+ memory cells proliferated for a shorter period of time than CD4+ naive cells because of their cytokine profile.61 The gene discussed is CD8A; the disease is neoplasm.