The endoplasmic reticulum membrane complex (EMC) consists of multiple proteins that are highly conserved across eukaryotes.1 This complex has been shown to play a critical role as a transmembrane protein insertase, facilitating the proper insertion of some tail-anchored membrane proteins and multipass transmembrane proteins.2,3 Of the ten proteins that form the human EMC, only variants in EMC1 have previously been associated with a genetic syndrome that includes global developmental delay (GDD), cerebellar atrophy, seizures, microcephaly, and vision abnormalities4,5 (OMIM 616875). Here, EMC1 is linked to Global developmental delay.