Accordingly, the concurrent inhibition of MRE11 and RAD51 impaired correct mitosis orchestration in neoR-CRC-SCs leading to accumulation of aberrant metaphases activating the spindle assembly checkpoint (SAC) [53] as shown by kinetochore localization of BUBR1 (BUBR1+pH3+ cells), along with an almost complete depletion of anaphases (Fig. 7g). This evidence concerns the gene BUB1B and colorectal carcinoma.