Mitotic defects were accompanied by the induction of apoptosis as demonstrated by the increased incorporation of the vital dye propidium iodide (Supplementary Fig. S8) coupled to increased activation of caspase-3 (Fig. 7h) in neoR-CRC-SCs cotreated with MRE11i and RAD51i. Here, CASP3 is linked to colorectal carcinoma.