AKT1 and precursor B-cell acute lymphoblastic leukemia: Since the PI3K/AKT/mTOR pathway is often upregulated in B-ALL in Hispanic/Latino children [33, 40], we tested the effect of CK2 inhibition on IKAROS’s ability to regulate MTOR transcription in primary B-ALL cells from pediatric patients that were Hispanic/Latino (patients 2 and 3), as well as non-Hispanic/Latino (patient 4).