Together, these data demonstrate that CK2 inhibition in high-risk B-ALL cells with the deletion of one IKZF1 allele, including those from Hispanic/Latino children, restores IKAROS’ ability to bind DNA, induces formation of repressive chromatin at the MTOR promoter, and represses transcription of MTOR. The gene discussed is IKZF1; the disease is acute lymphoblastic leukemia.