TNIK on chromosome 1 plays several functions in embryonic development, especially during the early embryo to blastocyst stages, participates in the regulation of the inflammatory response against infections83, TYW1B on chromosome 24 influences artery disease and blood pressure in human84, USH2A on chromosome 12 may be involved in the function of synapses and plays an important role in the development and maintenance of cells in the inner ear and retina85. Here, TYW1B is linked to arterial disorder.