However, an opposite pattern was identified for other of them (VEGFR2/KDR, CYR61/CCN1, IGFBP1, IGFBP4, IGFP6) and no changes for CTGF/CCN2, and IGFP6 across the breast cancer subtypes (Fig. 7A and Supplementary Fig. 4A and B). This evidence concerns the gene IGFBP4 and breast cancer.