Consistently with this, quantitative analysis of the RNA levels of VEGF indicated a selective reduction of VEGFA (the isoform mainly involved in tumor angiogenesis [20]) but not of VEGFB and VEGFC, and upregulation of its receptor VEGFR2 (which might indicate a compensatory mechanism following reduced VEGFA) in ERO1 KO MDAMB231m under hypoxia (Fig. 3B). This evidence concerns the gene VEGFA and neoplasm.