There are recent literatures indicating PD-1/PD-L1 blockade monotherapy may be the optimal therapeutic schedule in NSCLC patients harboring KRAS mutations, with KRAS mutations correlating with an inflammatory tumor microenvironment and tumor immunogenicity and thus resulting in superior patient response to PD-1/PD-L1 inhibitors51,52. This evidence concerns the gene CD274 and non-small cell lung carcinoma.