We performed thorough mechanistic studies elucidating the biological effects of MN-anti-miR10b3,5,6 and showed that MN-anti-miR10b affects molecular processes downstream of E-cadherin and, through its effect on HOXD10 and c-JUN profoundly inhibits the capacity of tumor cells to migrate and invade surrounding tissue and induces apoptosis in metastatic tumor cells. The gene discussed is CDH1; the disease is neoplasm.