In liver, gene expression of the lipogenic sterol regulatory element binding transcription factor 1 (SREBF1) was up-regulated in HF compared with SC pigs, while expression of the lipogenic activators insulin induced gene 1 (INSIG1) and thyroid hormone-inducible hepatic protein (THRSP) as well as the key DNL enzymes acetyl-CoA carboxylase alpha (ACACA), ATP citrate lyase (ACLY), and fatty acid synthase (FASN) were all surprisingly down-regulated. Here, FASN is linked to hydrops fetalis.