HAVCR2 and neoplasm: Potential ligand-receptor interactions were observed between Treg_C4_TNFRSF4 and CD8_C11_PDCD1 cells, including those of chemokines (CCL4-CCR8), adhesive connection (ITGAL-ICAM1 and SELPLG-SELL), and immune regulation (HAVCR2-LGALS9; Fig. 6b and Supplementary Data 6), which are well-known in the TME of tumour and promote the immune-suppressive activity of Treg cells and CD8+ T cells exhaustion26,38.