We also observed potential interacting pairs between EP_C1_LMP1 cells with activated Notch pathway and multiple cell types through NOTCH1-TNF and NOTCH2-JAG2, which have been related to radiation sensitivity40 and cancer stem-like side population cells41 in NPC (Supplementary Fig. 12d). The gene discussed is NOTCH2; the disease is nasopharyngeal carcinoma.