MYC and neoplasm: Noteworthily, the P02, P08, P11, and P15 samples with a higher proportion of C4 cluster compared to other samples showed enrichment of cell cycle (E2F, MYC, and G2M checkpoint) related pathways (Supplementary Fig. 10e–g), although C4 cluster had the highest proliferation scores but overall low content in NPC tumours compared to the other three clusters.