Particularly, B_C4_IFITM3, B_C5_ISG15, and B_C6_HSPA1A had the enrichment of ‘EBV infection’, ‘defence response to virus’, ‘viral carcinogenesis’, and ‘response to interferon-gamma’ pathways, suggesting that the three groups of cells might be responsible for the immune response against EBV infection (Supplementary Fig. 7d). This evidence concerns the gene IFITM3 and Epstein-Barr virus infection.