BHLHE40 and neoplasm: Besides, we identified two clusters of CD4+ Th1-like cells in tumours, including Th1_like_C1_CCR7 and Th1_like_C2_TNF, with specific expression of naïve T cell markers and pro-inflammatory cytokines, respectively, as well as a common expression of Th1-like cell markers21 (CXCL13, BHLHE40, and CXCR3; Supplementary Fig. 2d).