Considering that RIB and MAN induced depressive/anxiety-like behavior and spatial memory impairment, which, respectively, correlated with the insulin-POMC-MEK-TCF7L2 and MAPK-CREB-GRIN2A-CaMKII pathways, the issue of whether inhibition of these pathways could circumvent the effects of RIB and MAN requires further investigation in future studies. This evidence concerns the gene MAP2K7 and Anxiety.