ERG and neoplasm: In agreement with our previous results, we found that ERG-fused cells (VCaP, LuCaP-23.1, −35) were more sensitive to SPOP-i than ERG-negative cells (22Rv1, LNCaP, PC3), while SPOP mutant cells (LuCaP-78, −147) were particularly insensitive in 3D culture models and in xenograft tumor models in vivo (Fig. 7a–f and Supplementary Fig. 11e).