SOD1 and cartilage-hair hypoplasia: Prior to this study, sequence analysis of the nine major causative genes for CHH (ANOS1, CHD7, FGFR1, FGF8, GNRHR, GNRH1, KISS1R, PROKR2, and TACR3) was performed for all except for 13 (eight with CPHD, two with isolated normosmic HH, two with SOD, and one with Kallmann syndrome) cases4.