In addition, lower methylation levels of BIN1 promoter were also associated with increased CSF p-tau (β = −26.9626, p = 0.0028) and t-tau (β = −22.1300, p = 0.0130) in SCD subgroup, while these associations were not found in CN subgroup (Table 2). Here, BIN1 is linked to Schnyder corneal dystrophy.