The host-protective role of SIRT3 after infection appears to be restricted to M. tuberculosis, rather than a generalized phenomenon, since Sirt3−/− mice do not have an altered bacterial burden and survival when subjected to endotoxemia, Escherichia coli peritonitis, Klebsiella pneumoniae pneumonia, listeriosis, or candidiasis (46). This evidence concerns the gene SIRT3 and infection.