The host-protective role of SIRT3 after infection appears to be restricted to M. tuberculosis, rather than a generalized phenomenon, since Sirt3−/− mice do not have an altered bacterial burden and survival when subjected to endotoxemia, Escherichia coli peritonitis, Klebsiella pneumoniae pneumonia, listeriosis, or candidiasis (46). The gene discussed is SIRT3; the disease is serum lipopolysaccharide activity.