The specific ablation of RORγt in Foxp3+ Tregs was sufficient to exacerbate 2,4,6-Trinitrobenzenesulfonic acid (TNBS)-induced colitis driven by pathogenic Th1 and Th17 cells (44) but also the Th2-driven pathology of oxazolone-induced colitis (70). This evidence concerns the gene FOXP3 and colitis.