Interestingly, a significant reduction in wet weight and adipocyte hypertrophy was observe in epididymal WAT of adipocyte-specific TRAF6-KO mice on a high fat diet (HFD), which suggests TRAF6 inhibition in adipocytes could relieve the obesity induced by a HFD [19]. This evidence concerns the gene TRAF6 and obesity due to melanocortin 4 receptor deficiency.