INT777 (6α-ethyl-23(S)-methyl-cholic acid; 6-EMCA) is a specific TGR5 agonist without farnesoid X receptor activity; research has shown that intracerebroventricular injection of INT777 significantly improves amyloid-beta (Aβ) 1–42-induced cognitive impairment [41]. The gene discussed is NR1H4; the disease is Cognitive impairment.