While higher intake of total dietary fiber both at age of 13–18 and 19–30 years was also significantly associated with decreased NPC risk with dose-response relationships in Model 1 (OR in the highest versus the lowest quartile = 0.56, 95% CI = 0.40–0.79, P for trend = 0.006, and 0.49, 0.37–0.66, 0.003, respectively), these dose-response relationships became non-significant after additionally adjusting for EBV VCA-IgA in Model 2, and sun exposure and 25OHD in Model 3. This evidence concerns the gene CD79A and nasopharyngeal carcinoma.