NT-proBNP remained a strong predictor of risk irrespective of traditional confounders as age, eGFR, sex, hypertension, smoking, dyslipidaemia, BMI, baseline CVD and albumin/creatinine ratio for both CVD death (ln[NT-proBNP per IQR increase] adjusted HR: 3.96 [2.93–5.35], p < 0.001) and all-cause death (ln[NT-proBNP per IQR increase] adjusted HR: 2.25 [1.85–2.73], p < 0.001). Here, ALB is linked to inherited lipid metabolism disorder.