NPPB and type 2 diabetes mellitus: Our results demonstrate that (i) the ESC/EASD risk stratification model performs limited compared to SCORE and NT-proBNP in terms of risk prediction and discriminatory accuracy (ii) application of SCORE in a selected subgroup of T2DM patients resulted in a similar discriminative ability as achieved in non-diabetics, (iii) in both unselected and selected T2DM patients NT-proBNP remains a robust predictor for outcome, (iv) in contrast to NT-proBNP the ESC/EASD and SCORE risk model showed no outcome specifity for future CVD events in T2DM individuals.