SIRT1 and brain injury: In addition, the members of SIRT family reported could be targeted by miRNAs to further affect the biological function of series kinds of cells, for example, the upregulated SIRT1 by miR-34a was required for the differentiation of smooth muscle cell [26]; SIRT1 also could be targeted by miR-34a, miR-132, and miR-217 in the progress of astrocytoma [27]; SIRT2 could be targeted by miR-212 to alleviate the ischemic brain injury [28]; SIRT5 is targeted by miR-299-3p to suppress the migration, invasion, and proliferation of liver cancer cells [29].