To further investigate the exact expression profile of HRD1 in different breast cancer subtypes, we initially examined the protein and mRNA level in three breast cancer cell lines of luminal subtype (MCF-7, T47D, BT-474) and two basal-like (TNBC) cell lines including MDA-MB-231 and BT549 [18]. Here, SYVN1 is linked to breast cancer.