Specifically, recent studies showed that E3 ubiquitin ligases TRIM56 and RNF208 decrease cell migration and invasion of ovarian and breast cancer respectively by inducing polyubiquitination-mediated proteasomal degradation of Vimentin, suggesting that the suppression of Vimentin ameliorates metastasis in aggressive cancers [11, 12]. Here, RNF208 is linked to cancer.