However, when the HPA-1a/2a/3a haplotype was considered as reference (OR = 1.00), there was a statistically significant association of HPA-1b/2a/3b (P = 0.015, OR = 2.792, 95% CI 1.45–8.59) with CAD risk in the multivariate regression analysis upon adjusting for the confounding factors (Table 5). This evidence concerns the gene HPSE and coronary artery disorder.