The downregulated DEGs were linked to Circadian entrainment, Alcoholism, Aldosterone-regulated sodium reabsorption, Maturity onset diabetes of the young, cGMP-PKG signaling pathway, Dopaminergic synapse, Morphine addiction, Systemic lupus erythematosus, Glutamatergic synapse, Glycine, serine and threonine metabolism, Retrograde endocannabinoid signaling, Renin secretion. This evidence concerns the gene REN and alcohol dependence.