The downregulated DEGs were linked to Circadian entrainment, Alcoholism, Aldosterone-regulated sodium reabsorption, Maturity onset diabetes of the young, cGMP-PKG signaling pathway, Dopaminergic synapse, Morphine addiction, Systemic lupus erythematosus, Glutamatergic synapse, Glycine, serine and threonine metabolism, Retrograde endocannabinoid signaling, Renin secretion. Here, REN is linked to systemic lupus erythematosus.