Treatment for hemophilia A or B involves routine administration of exogenous coagulation factors to replace the missing/deficient endogenous FVIII or FIX, respectively [25]: This treatment implementation has changed continuously through the years in terms of products used (i.e., by-pass agents for patients with inhibitors, recombinant and monoclonal antibody drugs replacing Factor VIII) and administration method (on demand and prophylaxis administration) [25]. The gene discussed is F8; the disease is hemophilia A.