Remarkably, a PS-GAMP-conjugated influenza vaccine, induced protection against a broad range of influenza variants in mouse and ferret models; the administration of a single variant-containing vaccine and PS-GAMP led to the intrasubtype-specific IgG and IgA production, the activation of CD8+ CTLs, and high frequency of CD8+ TRM cells in the lungs. Here, CD79A is linked to influenza.