The TP53, NF1, NRAS, CDK4, MYCN, GLI, MDM2, FGFR1, and FGFR4 are listed among the most frequently altered in these tumours, interestingly they play a role in the cell cycle regulation and DNA repair, and interact with BARD1 [55,56]. The gene discussed is CDK4; the disease is neoplasm.