CXCL8 and cystic fibrosis: This is of interest since miR-155-5p deserves consideration for several reasons: (a) it can target NHERF2, another CFTR positive regulator [66]; (b) it has been demonstrated to be involved in cystic fibrosis by regulating FOXO1 [67]; (c) it is expected to regulate TCF4 [68], a transcription factor positively affecting CFTR expression [69]; and (d) promotes inflammatory responses following miR-155 dependent hyperactivation of IL-8 [70].