Correspondingly, USP2 knockdown decreased antiviral activity in embryonic kidney 293T cells, HepG2 cells, fibrosarcoma 2fTGH cells, and epidermoid KB cells against the vascular stomatitis virus (VSV); in human vascular endothelial cells against the dengue virus; and in lung cancer A549 cells against the influenza A virus (H1N1 strain) [154]. This evidence concerns the gene USP2 and lung cancer.