Murate and his colleagues reported that the expression of ASAH1 mRNA, which encodes ACDase, did not correlate with ACDase protein levels in an androgen-sensitive prostate cancer cell line (LNCaP); however, administration of either an androgen receptor antagonist or charcoal-stripped serum decreased ACDase protein levels via a proteasome-dependent mechanism [70]. Here, ASAH1 is linked to Familial prostate cancer.