IL6 and serum lipopolysaccharide activity: The role of IL-6 is controversial because it is an inflammatory cytokine involved in Th17 differentiation and its plasma concentration correlated with Th1 in SAT from adipose-tissue biopsies of overweight/obese individuals [113], but IL-6 release from exercising muscle has been suggested to inhibit the LPS-induced TNF-α production [116], limiting inflammation during endotoxemia [117].