In a phase 3 trial subgroup analysis of the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF), the authors reported that reduced renal function (creatinine clearances < 80 mL/min) had no impact on rivaroxaban’s effectiveness and safety [75]. Here, F10 is linked to stroke disorder.