Directly downregulates MYCN and AURKA in neuroblastoma cells, which can potentially have a negative impact on their survival; miR-186 upregulation in NK cells resulted in the downregulation of TGFBR1 and TGFBR2 and, thus, impaired the TGFβ1-dependent inhibition of NK cells’ cytotoxicity. The gene discussed is MYCN; the disease is neuroblastoma.