Table 4 details the results of the multivariate analysis of prognostic factors for OS. As reported, among MELD score, BILCHE score, BCLC stages, number of tumor, size of tumor, value of serum AFP, tumor grading, microvascular invasion, cirrhosis, SUVmax, SUVmean, SUVliver, MTV, photopenic areas, MTB and SUVratio, only the BCLC stages (HR = 2.94; 95%CI = 1.41–4.51; p = 0.003) and MTV (HR = 2.11; 95%CI = 1.51–3.45; p = 0.026) were found to be independently associated with OS. This evidence concerns the gene AFP and Cirrhosis.