TP53 and breast cancer: Breast cancer (BRCA1/2) gene carriers who underwent prophylactic salpingo-oophorectomy were shown to have precursor lesions with TP53 mutation, including p53 signature, serous intraepithelial lesion (STIL), and less commonly, serous tubal intraepithelial carcinoma (STIC) in the fallopian tube epithelium (FTE) [6,7].