Neurotoxicity via elevating COX-2 expression was noted in neurodegenerative diseases, such as multiple sclerosis, amyotrophic lateral sclerosis, and Parkinson and Alzheimer diseases; meanwhile, the inhibition of COX-2 expression promoted neuroprotective effects, according to several experiments [26,27,28]. The gene discussed is PTGS2; the disease is Parkinsonism.