PTGS2 and early-onset autosomal dominant Alzheimer disease: Neurotoxicity via elevating COX-2 expression was noted in neurodegenerative diseases, such as multiple sclerosis, amyotrophic lateral sclerosis, and Parkinson and Alzheimer diseases; meanwhile, the inhibition of COX-2 expression promoted neuroprotective effects, according to several experiments [26,27,28].