BTK and rheumatoid arthritis: At 1 μM, KMU-1170 significantly suppressed LPS-induced increase of IL-1β protein in THP-1 cells, whereas this effect was not observed even at higher concentrations of other tested drugs, such as celecoxib (COX-2 inhibitor), ibrutinib (BTK inhibitor), ruxolitinib (JAK inhibitor) and methotrexate (Anti-inflammatory drug of RA) (Figure 5C,D).