SNCA and Parkinsonism: Moreover, comparable changes observed on a molecular level, such as defects in vesicular trafficking, endocytosis, and the actin cytoskeleton, and increased calcineurin activity in yeast Parkinson’s alpha-synuclein model [29] and VPS13-deficiency model [46], which includes early-onset Parkinsonism, suggest that a similar approach can be taken for the treatment of several diseases.