ETV2 and viral infectious disease: While a small fraction (20%) of ETV2 viral infection does not interfere with the development of cortical structures or transcriptional and morphological features of the vascularized cerebral organoids (vhCOs), ETV2 promotes early formation of CD31 positive endothelial tubes that continuously evolve with increased structural complexity and robust expression of endothelial markers in the lumen of ventricular-like zones compared to the control.